Abstract: The safety of uranium tailings pond is closely related to social stability and economic development, so it is necessary to improve the emergency management of uranium tailings pond to ensure its safety by adjusting the emergency plan. The Interpretive Structural Model (ISM) is used to analyze the structural relationship between the main risk factors leading to the occurrence of emergencies. The results show that attention should be paid to the risk factors originating from humans and infrastructures, and effective management measures should be adopted in the process of emergency management, for example, people build tighter employee access system, clarify the responsibilities of employees at all levels, and improve monitoring and organizational means. According to the results of ISM analysis, a structural risk control system can be constructed, and a defensive barrier that can effectively block the risk coupling transmission can be designed to prevent the risk from being transformed into an event. For other risks, system resilience management should be strengthened to respond to risks. The process is set as emergency response and accident response. Different management objects use different management methods to make emergency management work efficiently.